Description

8-Chloro-6,7-Difluoro-1-[(1S,2R)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key chiral synthon in the synthesis of novel, potent fluoroquinolone antibiotics, valued for its structural complexity and defined stereochemistry. It is essential for pharmaceutical R&D and manufacturing organizations focused on developing next-generation antibacterial agents with improved efficacy and safety profiles.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of advanced fluoroquinolone antibiotics.
• Antibacterial Drug Development: Serves as a core scaffold for research into new antibacterial compounds targeting resistant bacterial strains.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step production of final drug substances.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing for clinical trial material.
• Chemical Reference Standard: Utilized as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Academic & Contract Research: Supports medicinal chemistry programs and structure-activity relationship (SAR) studies in academic and CRO settings.

Basic Information

Product Name	8-Chloro-6,7-Difluoro-1-[(1S,2R)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	127199-26-2
Molecular Formula	C13H7ClF3NO3
Molecular Weight	329.65 g/mol
Synonyms	(1S,2R)-1-(8-Chloro-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate)-2-fluorocyclopropane; 8-Chloro-6,7-difluoro-1-[(1S,2R)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; (1S,2R)-2-Fluorocyclopropyl 8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; Sitafloxacin Intermediate; DU-6859a Intermediate; Gracevit Intermediate; Advanced Fluoroquinolone Intermediate; Chiral Quinoline Derivative
EINECS	Contact for details

Quality Control

Our 8-Chloro-6,7-Difluoro-1-[(1S,2R)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All batches undergo comprehensive analytical testing, including chiral purity verification, to meet stringent customer specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1S,2R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.