Description

(Cys8·13)-Dynorphin A (1-13) Amide H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-Arg-Pro-Lys-Leu-Cys-Nh2 (Disulfide Bond) is a synthetic, cyclic peptide analog of the endogenous opioid peptide Dynorphin A. This compound is of significant interest for its role in neuroscience and pharmacology research, particularly in studying κ-opioid receptor (KOR) signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in neuropeptide research and drug discovery.

Application

• Neuroscience Research: As a potent and selective κ-opioid receptor (KOR) agonist for studying pain modulation, stress responses, and reward pathways.
• Pharmacological Studies: Used in in vitro and in vivo assays to investigate receptor binding affinity, signal transduction, and physiological effects of dynorphin peptides.
• Drug Discovery & Development: Serves as a reference standard or a lead compound in the development of novel analgesics and neuropsychiatric therapeutics targeting the opioid system.
• Biochemical Research: Employed in studies of peptide structure-activity relationships (SAR) due to its stabilized cyclic structure from the disulfide bond.
• Cell Signaling Research: A tool for exploring the role of dynorphin in cellular processes such as apoptosis and neurotransmitter release.

Basic Information

Product Name	(Cys8·13)-Dynorphin A (1-13) Amide H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-Arg-Pro-Lys-Leu-Cys-Nh2 (Disulfide Bond)
CAS No.	127103-91-7
Molecular Formula	C78H128N30O16S2
Molecular Weight	1782.2 g/mol
Synonyms	Dynorphin A (1-13) amide, cyclic (8-13)-disulfide; [Cys8,Cys13]-Dynorphin A (1-13) amide; Cyclic Dynorphin A (1-13) amide; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-Arg-Pro-Lys-Leu-Cys-NH2 (cyclic 8-13 disulfide); Dynorphin A (1-13)NH2, cyclic (Cys8-Cys13); [Cys8, Cys13] Dynorphin A (1-13) amide
EINECS	Contact for details

Quality Control

Our (Cys8·13)-Dynorphin A (1-13) Amide is produced under strict quality management systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry for identity confirmation, to ensure batch-to-batch consistency and reliability. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.