Description

Cgp 42112 is a high-purity, non-peptide angiotensin II receptor antagonist used in biochemical and pharmacological research. This compound is a critical tool for studying the renin-angiotensin system and its role in cardiovascular regulation. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors who require reliable, well-characterized reference standards for receptor binding studies and assay development.

Application

• Biochemical Research: Used as a selective AT1 receptor antagonist in receptor binding assays and signal transduction studies.
• Pharmacological Studies: A key tool for investigating the physiological and pathophysiological roles of angiotensin II in cardiovascular and renal systems.
• Drug Discovery & Development: Serves as a reference compound for screening and validating new angiotensin receptor blockers (ARBs).
• Academic Research: Utilized in university and institutional labs for fundamental research on hypertension and related disorders.
• In Vitro Diagnostics: Can be employed in the development of specialized diagnostic assays targeting the renin-angiotensin pathway.

Basic Information

Product Name	Cgp 42112
CAS No.	127060-75-7
Molecular Formula	C22H28N6O4
Molecular Weight	440.50 g/mol
Synonyms	Nα-Nicotinoyl-Tyr-(Nα-benzyloxycarbonyl-Arg)Lys-His-Pro-Ile; CGP-42112; CGP 42112A; CGP42112; (Nicotinoyl-Tyr-(Nα-Cbz-Arg)LysHisProIle); Angiotensin II AT1 Receptor Antagonist (non-peptide)
EINECS	Contact for details

Quality Control

Our Cgp 42112 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.