Description

Bradykinin, Sar-(D-Phe(8))Des-Arg(9) CAS NO 126959-88-4 is a synthetic peptide analog of bradykinin, specifically designed as a potent and selective antagonist for the B1 receptor subtype. This compound is a critical research tool for investigating the kallikrein-kinin system, which plays a significant role in inflammation, pain, and cardiovascular regulation. It is essential for pharmaceutical R&D, academic research, and diagnostic development focused on receptor pharmacology and inflammatory pathways.

Application

• Pharmacological Research: Used as a selective B1 receptor antagonist to study receptor function, signal transduction, and ligand-receptor interactions in vitro and in vivo.
• Inflammation and Pain Studies: A key tool for elucidating the role of the kinin system in inflammatory processes, neurogenic inflammation, and chronic pain models.
• Cardiovascular Research: Employed in studies investigating the effects of kinins on blood pressure regulation, vascular permeability, and heart function.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel anti-inflammatory and analgesic therapeutics targeting the B1 receptor.
• Diagnostic Assay Development: Utilized in the development and validation of competitive binding assays (e.g., ELISA, RIA) and functional cellular assays for B1 receptor activity.
• Academic & Institutional Research: Provides a reliable, high-purity reagent for basic science research in physiology, pharmacology, and molecular biology departments.

Basic Information

Product Name	Bradykinin, Sar-(D-Phe(8))Des-Arg(9)
CAS No.	126959-88-4
Molecular Formula	C52H74N14O11
Molecular Weight	1047.2 g/mol
Synonyms	Sar-[D-Phe8,des-Arg9]-Bradykinin; B1 Receptor Antagonist; [Sar1, D-Phe8, des-Arg9]-Bradykinin; H-Sar-Arg-Pro-Pro-Gly-Phe-Ser-D-Phe-Phe-OH; Lys-des-Arg9, Leu8]-bradykinin analog; B-9430 (Research Code); Bradykinin B1 Antagonist; Selective Bradykinin B1 Receptor Antagonist
EINECS	Contact for details

Quality Control

Every batch of Bradykinin, Sar-(D-Phe(8))Des-Arg(9) is manufactured and analyzed under strict quality management systems. We guarantee high purity and consistency suitable for advanced research applications. Comprehensive testing includes identity confirmation by mass spectrometry (MS) and chromatography, purity assessment by HPLC, and verification of biological activity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.