Description

2-Chlorohistidine is a halogenated derivative of the essential amino acid L-histidine, featuring a chlorine atom substitution that modifies its biochemical properties. This modification makes it a valuable synthetic intermediate and research chemical for probing enzyme mechanisms and developing novel bioactive compounds. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in peptide synthesis and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel peptide-based drugs and enzyme inhibitors.
• Biochemical Research: Used as a substrate analog to study the activity and specificity of histidine-decarboxylating enzymes and other histidine-processing proteins.
• Proteomics & Peptide Chemistry: Incorporated into synthetic peptides to alter structure-activity relationships, stability, or binding affinity.
• Metabolic Pathway Studies: Serves as a tool to investigate histidine metabolism and related pathways in biological systems.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Chlorohistidine
CAS No.	126663-37-4
Molecular Formula	C6H10ClN3O2
Molecular Weight	191.62 g/mol
Synonyms	2-Chloro-L-histidine; (2S)-2-Amino-3-(2-chloro-1H-imidazol-4-yl)propanoic acid; L-2-Chlorohistidine; 2-Cl-His; 2-Chloroimidazole-4-alanine; Histidine, 2-chloro-
EINECS	Contact for details

Quality Control

Our 2-Chlorohistidine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality parameters include identity confirmation, assay (purity), and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.