Description

2-Bromohistidine is a halogenated derivative of the essential amino acid histidine, serving as a critical building block in advanced organic synthesis and pharmaceutical research. This modified amino acid is particularly valuable for introducing specific bromine functionality into peptide chains, enabling the study of protein structure, function, and interactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, enzyme inhibitors, and diagnostic probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme active sites where histidine residues are involved.
• Peptide Chemistry & Bioconjugation: Used to incorporate a bromine handle into synthetic peptides for site-specific labeling, cross-linking studies, or further functionalization via click chemistry.
• Biochemical Research: Employed as a tool compound to study enzyme mechanisms, protein-ligand interactions, and the role of histidine in catalytic processes by acting as an analog or inhibitor.
• Proteomics & Chemical Biology: Facilitates the development of activity-based probes and affinity tags for identifying and characterizing proteins in complex biological systems.
• Material Science: Potential use in the synthesis of functionalized polymers or biomaterials that require specific amino acid-based motifs for biocompatibility or recognition.

Basic Information

Product Name	2-Bromohistidine
CAS No.	126663-36-3
Molecular Formula	C6H9BrN3O2
Molecular Weight	235.06 g/mol
Synonyms	2-Bromo-L-histidine; L-Histidine, 2-bromo-; (2S)-2-Amino-3-(2-bromo-1H-imidazol-4-yl)propanoic acid; Bromohistidine; 2-Bromoimidazole-4-alanine; Histidine, 2-bromo-
EINECS	Contact for details

Quality Control

Our 2-Bromohistidine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.