Description

n-Fmoc-8-Aminooctanoic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a crucial building block for introducing a flexible, hydrophobic spacer arm into synthetic peptides, enabling advanced research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs focused on developing peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of 8-aminooctanoic acid (a C8 spacer) into peptide chains, enhancing solubility and conformational flexibility.
• Linker Chemistry: Used in the synthesis of peptide-drug conjugates (PDCs) and antibody-drug conjugates (ADCs) where a stable, cleavable linker is required.
• Bioconjugation: Facilitates the site-specific attachment of peptides to surfaces, nanoparticles, or other biomolecules for diagnostic and sensor applications.
• Structure-Activity Relationship (SAR) Studies: Employed to systematically modify peptide length and hydrophobicity to optimize biological activity and pharmacokinetic properties.
• Combinatorial Library Synthesis: A valuable scaffold for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Biomaterial Functionalization: Used to create peptide-modified surfaces that promote specific cellular interactions for tissue engineering.

Basic Information

Product Name	n-Fmoc-8-Aminooctanoic Acid
CAS No.	126631-93-4
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-8-Aoc-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-8-aminooctanoic Acid; 8-[(9-Fluorenylmethyloxycarbonyl)amino]octanoic Acid; Fmoc-Aminooctanoic Acid; Fmoc-8-Aminocaprylic Acid; N-Fmoc-8-Aminooctanoic Acid; (8-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}octanoic acid); Fmoc-AOC-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-8-Aminooctanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.