Description

5-Bromo-6-(Trifluoromethyl)Pyrimidin-4-Ol is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of bromine and trifluoromethyl substituents on the pyrimidine scaffold, enabling precise molecular modifications and the introduction of desirable physicochemical properties. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and metabolic stability.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Chemical Biology Probe: Serves as a versatile scaffold for designing molecular probes and tools to study biological pathways and enzyme functions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex molecular architectures.
• Fluorine Chemistry Research: A valuable compound for investigating structure-activity relationships (SAR) influenced by the potent trifluoromethyl group.

Basic Information

Item	Detail
Product Name	5-Bromo-6-(Trifluoromethyl)Pyrimidin-4-Ol
CAS No.	126538-81-6
Molecular Formula	C5H2BrF3N2O
Molecular Weight	242.98 g/mol
Synonyms	4-Hydroxy-5-bromo-6-(trifluoromethyl)pyrimidine; 5-Bromo-6-(trifluoromethyl)-4-pyrimidinol; 5-Bromo-6-(trifluoromethyl)-4(1H)-pyrimidinone; 5-Bromo-6-(trifluoromethyl)pyrimidin-4(3H)-one; 5-Bromo-6-trifluoromethyl-4-pyrimidinol; 4-Pyrimidinol, 5-bromo-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-(Trifluoromethyl)Pyrimidin-4-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.