Description

4-Bromo-6-Chloropyrimidine is a versatile halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Material Science Research: Serves as a building block for creating functionalized polymers, ligands for metal-organic frameworks (MOFs), and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design of chemical probes and affinity tags for studying enzyme function and protein interactions.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig).
• Nucleic Acid Chemistry: Useful in the modification of nucleosides and nucleotides for antisense or diagnostic applications.

Basic Information

Product Name	4-Bromo-6-Chloropyrimidine
CAS No.	126401-90-9
Molecular Formula	C4H2BrClN2
Molecular Weight	193.43 g/mol
Synonyms	6-Chloro-4-bromopyrimidine; 4-Bromo-6-chloro-1,3-diazine; Pyrimidine, 4-bromo-6-chloro-; 4-Bromo-6-chloro-pyrimidine; 4-Br-6-Cl-Pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Bromo-6-Chloropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.