Description

3-Quinolinecarboxylic Acid, 1-(4-Aminophenyl)-6-Fluoro-1,4-Dihydro-4-Oxo-7-(1-Piperazinyl)- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key structural moiety in the synthesis of modern fluoroquinolone antibiotics, valued for its role in creating potent antibacterial agents. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel fluoroquinolone antibiotic candidates.
• API (Active Pharmaceutical Ingredient) Manufacturing: Used in the production scale-up of antibacterial drugs targeting resistant pathogens.
• Research & Development: Serves as a core scaffold in medicinal chemistry for designing and testing new antimicrobial agents.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized chemical entities.
• Biochemical Research: Used in studies investigating bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-(4-Aminophenyl)-6-Fluoro-1,4-Dihydro-4-Oxo-7-(1-Piperazinyl)-
CAS No.	126362-91-2
Molecular Formula	C20H18FN5O3
Molecular Weight	395.39 g/mol
Synonyms	1-(4-Aminophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 7-(1-Piperazinyl)-1-(4-aminophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; 6-Fluoro-1-(4-aminophenyl)-7-piperazin-1-yl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; GTX Intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Related Compound
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided, and production can be aligned with cGMP standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.