Description

H-p-Amino-D-Phe-Oh Hcl is a high-purity, non-natural amino acid derivative, specifically the D-isomer of para-aminophenylalanine hydrochloride. This compound is a critical chiral building block in advanced pharmaceutical synthesis and peptide research, valued for its precise stereochemistry and functional group. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides, peptidomimetics, and as a key intermediate in active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based drugs and APIs.
• Peptide Research & Development: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-para-aminophenylalanine residue, which can confer metabolic stability and alter biological activity.
• Bioconjugation & Linker Chemistry: The aromatic amino group serves as a handle for conjugation with dyes, tags, or other molecules in the development of antibody-drug conjugates (ADCs) and diagnostic probes.
• Fine Chemical Synthesis: Employed as a building block for complex organic molecules requiring specific stereochemical and functional properties.
• Academic & Industrial Research: Essential for biochemical studies exploring enzyme specificity, receptor-ligand interactions, and structure-activity relationships (SAR).

Basic Information

Product Name	H-p-Amino-D-Phe-Oh Hcl
CAS No.	126257-07-6
Molecular Formula	C9H13ClN2O2
Molecular Weight	216.66 g/mol
Synonyms	(R)-2-Amino-3-(4-aminophenyl)propanoic acid hydrochloride; D-4-Aminophenylalanine hydrochloride; D-p-Aminophenylalanine HCl; H-D-Phe(4-NH2)-OH·HCl; Fmoc-D-4-Aminophenylalanine (precursor); D-4-Abz-OH·HCl (Abz = Aminobenzoic acid derivative); Boc-D-Phe(4-NH2)-OH·HCl (Boc-protected form); D-para-Amino-Phe-OH hydrochloride
EINECS	Contact for details

Quality Control

Our H-p-Amino-D-Phe-Oh Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.