Description

L-(+)-2-Amino-6-Phosphonohexanoic Acid is a high-purity, enantiomerically pure phosphonic acid derivative of the essential amino acid lysine. This compound is a potent and selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), making it a critical research tool in neuroscience and pharmacology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies investigating neurological pathways and developing novel therapeutics. The product is supplied under strict quality control to ensure batch-to-batch consistency for sensitive experimental applications.

Application

• Neuroscience Research: As a selective mGluR5 antagonist for studying glutamatergic signaling, synaptic plasticity, and neuronal excitability.
• Pharmacological Studies: Used in vitro and in vivo to validate mGluR5 as a drug target for conditions like anxiety, depression, Fragile X syndrome, and Parkinson's disease.
• Biochemical Assay Development: Serves as a reference standard and key reagent in high-throughput screening (HTS) assays for drug discovery programs.
• Academic & Institutional Research: A fundamental tool for university labs and research institutes exploring central nervous system (CNS) function and disorders.
• Preclinical Development: Used in animal models to establish proof-of-concept for mGluR5-targeting therapeutic candidates.

Basic Information

Product Name	L-(+)-2-Amino-6-Phosphonohexanoic Acid
CAS No.	126253-57-4
Molecular Formula	C6H14NO5P
Molecular Weight	211.15 g/mol
Synonyms	L-2-Amino-6-phosphonohexanoic acid; (S)-2-Amino-6-phosphonohexanoic acid; L-AP6; L-2-Amino-6-phosphonocaproic acid; L-APHA; mGluR5 antagonist LY 367385; (S)-AP6; LY-367385; (S)-2-Amino-6-phosphono-n-hexanoic acid
EINECS	Contact for details

Quality Control

Our L-(+)-2-Amino-6-Phosphonohexanoic Acid is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and potency for research applications. Standard quality checks include chiral purity verification, assay by HPLC, and control of related substances. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each batch to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L- enantiomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.