Description

1-(3,5-Di-o-(p-Toluoyl)-β-D-2-Deoxyribofuranosyl)-5-(2-(Phthalimidooxy)Ethyl)-4 (1,2,4-Triazol-1-Yl)-1H-Pyrimidin-2-One is a sophisticated nucleoside analog intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of novel antiviral and anticancer therapeutics, particularly in the synthesis of modified nucleosides. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to drive innovation in targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of experimental nucleoside analogs for antiviral and anticancer research.
• Antiviral Drug Development: Used in the research and production of potential therapeutic agents targeting viral polymerases.
• Oncology Research: Serves as a building block for creating novel chemotherapeutic candidates that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Probe Synthesis: Utilized to create labeled or modified nucleosides for studying enzymatic mechanisms and cellular processes.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs engaged in custom synthesis of complex molecules for clinical trials.

Basic Information

Product Name	1-(3,5-Di-o-(p-Toluoyl)-β-D-2-Deoxyribofuranosyl)-5-(2-(Phthalimidooxy)Ethyl)-4 (1,2,4-Triazol-1-Yl)-1H-Pyrimidin-2-One
CAS No.	126128-40-3
Molecular Formula	C43H38N6O8
Molecular Weight	766.80 g/mol
Synonyms	5-(2-(Phthalimidooxy)ethyl)-4-(1,2,4-triazol-1-yl)-1-[3,5-di-O-(4-methylbenzoyl)-β-D-2-deoxyribofuranosyl]pyrimidin-2(1H)-one; 1-(3,5-Di-O-p-toluoyl-β-D-2-deoxyribofuranosyl)-5-[2-(phthalimidooxy)ethyl]-4-(1,2,4-triazol-1-yl)pyrimidin-2(1H)-one; Protected Nucleoside Triazole Intermediate; 2'-Deoxyribofuranoside Intermediate; CAS 126128-40-3.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Each lot undergoes comprehensive analytical characterization, including HPLC purity assay, identity confirmation (IR, NMR), and specified impurity profiling. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.