Description

Dynorphin B (1-9) CAS NO 126050-26-8 is a bioactive nonapeptide fragment derived from the larger dynorphin B opioid peptide. This compound is of significant interest for its role as a highly selective κ-opioid receptor (KOR) agonist, making it a critical tool for neurological and pharmacological research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers investigating pain pathways, addiction mechanisms, and central nervous system disorders.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to elucidate the role of κ-opioid receptors in pain modulation, stress response, and reward pathways.
• Pharmacological Development: Serves as a reference standard and lead compound in the discovery and development of novel analgesic and neuropsychiatric therapeutics targeting the KOR system.
• Biochemical Assays: Employed in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other immunoassay kits for the quantitative detection and study of dynorphin-related peptides.
• Academic & Clinical Studies: Essential for university and hospital labs conducting fundamental research on opioid peptide physiology, neurotransmitter release, and behavioral pharmacology.
• Cell Signaling Research: Applied in studies of G-protein coupled receptor (GPCR) signaling cascades, intracellular calcium mobilization, and neuronal excitability.

Basic Information

Product Name	Dynorphin B (1-9)
CAS No.	126050-26-8
Molecular Formula	C₅₀H₇₄N₁₂O₁₂
Molecular Weight	1035.2 g/mol
Synonyms	Dynorphin B (1-9); Leu-Enkephalin-Arg-Arg-Ile-Arg-Pro-Lys; Dynorphin B Fragment 1-9; Dynorphin-32 (1-9); [Leu5]-Enkephalin-Arg-Arg-Ile-Arg-Pro-Lys; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys; Rimorphin (1-9); Dynorphin B Nonapeptide
EINECS	Contact for details

Quality Control

Our Dynorphin B (1-9) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.