Description

γ-Dendrotoxin is a selective and potent polypeptide neurotoxin isolated from the venom of the Eastern green mamba (*Dendroaspis angusticeps*). This high-purity biochemical is a critical tool for neuroscience research, specifically targeting and blocking certain voltage-gated potassium channels (Kv1.1, Kv1.2, and Kv1.6) in neuronal membranes. It is essential for researchers and pharmaceutical developers in neuropharmacology, ion channel studies, and the development of neurological therapeutics.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of voltage-gated potassium channels (Kv1 family) in central and peripheral nervous systems.
• Ion Channel Characterization: Used in patch-clamp electrophysiology and other assays to characterize subtype-specific potassium channel activity and pharmacology.
• Drug Discovery & Development: Serves as a reference standard and probe in high-throughput screening (HTS) campaigns for identifying novel neuroactive compounds targeting potassium channels.
• Biochemical Assays: Employed in binding studies and competitive inhibition experiments to understand receptor-ligand interactions at potassium channels.
• Academic & Pharmaceutical R&D: Fundamental for basic research into synaptic transmission, neuronal excitability, and pathophysiological mechanisms related to channelopathies.
• Toxicology Studies: Used as a precise toxin to investigate the effects of potassium channel blockade in various experimental models.

Basic Information

Product Name	γ-Dendrotoxin
CAS No.	126039-39-2
Molecular Formula	C388H602N112O111S12
Molecular Weight	~8530 g/mol
Synonyms	Dendrotoxin I; DTX-I; Toxin I (Dendroaspis angusticeps); γ-DTX; γ-Dendrotoxin I; Dendrotoxin K; Potassium channel toxin α-DTx; ShK-like toxin 1; Neurotoxin DTX
EINECS	Contact for details

Quality Control

Our γ-Dendrotoxin (CAS 126039-39-2) is produced and purified under stringent conditions to ensure the highest standards of biological activity and purity, suitable for sensitive research applications. Each batch is characterized by multiple analytical techniques, including HPLC for purity assessment and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, potency (where applicable), and analytical data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity	Assessed by functional assay (e.g., channel inhibition)
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.