Description

(D-Pro12)-α-Msh (11-13) CAS NO 125905-17-1 is a synthetic peptide fragment derived from the α-melanocyte-stimulating hormone (α-MSH) sequence, specifically modified with a D-proline residue at position 12. This modification enhances its metabolic stability and receptor selectivity, making it a valuable tool for biochemical and pharmacological research. It is primarily utilized by researchers in the pharmaceutical, biotechnology, and academic sectors for studying melanocortin receptor pathways, peptide hormone activity, and developing novel therapeutic agents.

Application

• Biomedical Research: As a key reference standard and active probe for investigating the structure-activity relationships (SAR) of melanocortin peptides and their interactions with MC1R and other receptor subtypes.
• Drug Discovery & Development: Serves as a critical intermediate or lead compound in the development of novel therapeutics targeting skin disorders, inflammation, and energy homeostasis.
• Pharmacological Studies: Used in in vitro and in vivo assays to study signal transduction, receptor binding affinity, and the physiological effects of α-MSH analogs.
• Peptide Chemistry & Synthesis: An important building block for chemists specializing in solid-phase peptide synthesis (SPPS) to create more complex, modified peptide sequences.
• Academic & Institutional Labs: Employed in university and research institute settings for fundamental studies in endocrinology, neurobiology, and peptide science.

Basic Information

Product Name	(D-Pro12)-α-Msh (11-13)
CAS No.	125905-17-1
Molecular Formula	C20H30N6O5
Molecular Weight	446.5 g/mol
Synonyms	Ac-Lys-Pro-Val-NH2 (D-Pro12 analog); [D-Pro12]-α-MSH (11-13); α-Melanocyte Stimulating Hormone (11-13) fragment, D-Pro12 analog; Ac-Lys-D-Pro-Val-NH2; Melanotropin (11-13) (pig), 12-D-proline-; (D-Pro12)-α-MSH(11-13); H-Ac-Lys-D-Pro-Val-NH2
EINECS	Contact for details

Quality Control

Every batch of (D-Pro12)-α-Msh (11-13) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Standard quality control includes HPLC for purity assessment, mass spectrometry (MS) for confirmation of molecular weight, and amino acid analysis (AAA). Our products are suitable for research use and are supported by comprehensive Certificates of Analysis (COA), which are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.