Description

Nomega-tert-Butoxycarbonyl-Nalpha-9-Fluorenylmethoxycarbonyl-L-Lysine is a protected derivative of the essential amino acid L-Lysine, featuring orthogonal tert-butoxycarbonyl (Boc) and fluorenylmethoxycarbonyl (Fmoc) protecting groups on its side chain and α-amino functionalities, respectively. This dual-protection strategy is critical for enabling precise, sequential peptide synthesis, particularly in Solid-Phase Peptide Synthesis (SPPS) methodologies. It is an indispensable building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc/Boc-protected amino acid for the controlled, stepwise assembly of peptide chains, especially where selective side-chain deprotection is required.
• Pharmaceutical Intermediates: Serves as a key raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation and Probe Development: Used to incorporate lysine residues with orthogonal protecting groups for subsequent labeling with fluorophores, biotin, or other functional moieties.
• Combinatorial Chemistry: Employed in libraries for drug discovery to create diverse arrays of compounds containing modified lysine residues.
• Research & Development: Essential for academic and industrial R&D focused on peptide structure-activity relationships, novel peptide design, and biochemical studies.

Basic Information

Item	Details
Product Name	Nomega-tert-Butoxycarbonyl-Nalpha-9-Fluorenylmethoxycarbonyl-L-Lysine
CAS No.	125814-22-4
Molecular Formula	C26H32N2O6
Molecular Weight	468.55 g/mol
Synonyms	Fmoc-Lys(Boc)-OH; Nα-Fmoc-Nε-Boc-L-lysine; Fmoc-Lys(Boc)-OH; Boc-Lys(Fmoc)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanoic acid; Nε-Boc-Nα-Fmoc-L-lysine; Fmoc-Lysine(Boc)-OH; Nα-Fmoc-Nε-Boc-L-Lysine
EINECS	Contact for details

Quality Control

Our Nomega-tert-Butoxycarbonyl-Nalpha-9-Fluorenylmethoxycarbonyl-L-Lysine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications like peptide synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under desiccant or inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.