Description

Fmoc-L-Thr[α-(Gal-Beta(1-3)-Galnac)]-Oh Peracetate is a sophisticated, protected glycopeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of complex O-linked glycan structures, specifically the Thomsen-Friedenreich (T or TF) antigen disaccharide, into synthetic peptides and glycopeptides. It is an essential reagent for researchers and manufacturers in glycobiology, pharmaceutical development, and diagnostic reagent production, enabling the study of glycosylation's role in disease and the creation of novel biotherapeutics and vaccines.

Application

• Solid-Phase Glycopeptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative, it is a key building block for the automated synthesis of glycopeptides containing the T-antigen (Gal-β(1-3)-GalNAc-α-O-Thr) motif.
• Glycobiology Research: Used to synthesize well-defined glycopeptide probes for studying protein-glycan interactions, immune recognition, and cell signaling pathways.
• Vaccine Development: Enables the construction of antigenic glycopeptide sequences for the development of cancer vaccines targeting tumor-associated carbohydrate antigens (TACAs).
• Pharmaceutical Intermediate: Serves as a critical intermediate in the research and development stages of novel biopharmaceuticals, including therapeutic antibodies and enzyme replacements.
• Diagnostic Reagent Manufacturing: Used to produce standardized glycopeptide antigens for immunoassays and diagnostic kits.
• Chemical Biology Tool Development: Facilitates the creation of tools for profiling glycosyltransferase activity or for cell-surface engineering studies.

Basic Information

Item	Detail
Product Name	Fmoc-L-Thr[α-(Gal-Beta(1-3)-Galnac)]-Oh Peracetate
CAS No.	125760-33-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fmoc-Thr(Gal-β(1-3)-GalNAcα)-OH peracetate; Fmoc-O-(3-O-β-D-galactopyranosyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-threonine peracetate; Fmoc-L-Threonine with O-(3-O-β-D-Galactopyranosyl-2-acetamido-2-deoxy-α-D-galactopyranosyl) peracetate; Fmoc-Tn antigen (Gal-β(1-3)-GalNAcα) building block; TF antigen glycopeptide building block; Fmoc-3'-O-β-D-galactosyl-α-D-N-acetylgalactosaminyl-L-threonine peracetate; Glycopeptide SPPS reagent (T-antigen)
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thr[α-(Gal-Beta(1-3)-Galnac)]-Oh Peracetate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS analysis, to confirm identity, purity, and the integrity of the protecting groups. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.