Description

Substance P (6-11), N(1,6)(β-Glucopyranosyl)Glu(5)-Pro(9)- is a chemically modified, bioactive fragment of the neuropeptide Substance P. This compound matters for advanced research in neuropharmacology and immunology, offering a tool to study receptor interactions and signaling pathways with enhanced specificity. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for pain, inflammation, and neurological disorders.

Application

• Neuroscience Research: A key tool for studying the role of Substance P and its receptors (NK1) in pain transmission, neurogenic inflammation, and central nervous system function.
• Immunology Studies: Used to investigate the modulation of immune cell activity and cytokine release mediated by neuropeptide signaling.
• Drug Discovery & Development: Serves as a reference standard or a lead compound in the design and screening of new analgesic and anti-inflammatory agents.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays and receptor binding studies.
• Cell Signaling Pathway Analysis: Utilized to elucidate specific intracellular pathways activated by modified neuropeptide fragments.
• Academic & Clinical Research: Supports fundamental research into the mechanisms of migraine, arthritis, asthma, and other conditions linked to neurokinin receptors.

Basic Information

Product Name	Substance P (6-11), N(1,6)(β-Glucopyranosyl)Glu(5)-Pro(9)-
CAS No.	125741-45-9
Molecular Formula	C38H60N10O17
Molecular Weight	904.95 g/mol
Synonyms	Substance P Fragment 6-11, Glucosylated; [Glc(β1)]Glu(5)-Pro(9)-Substance P (6-11); Nα-(6-O-β-D-Glucopyranosyl)-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Substance P (6-11) amide, 5-[6-O-(β-D-glucopyranosyl)-L-glutamine]; Glycosylated Substance P analog; Neurokinin receptor ligand analog; SP (6-11) glycosylated derivative
EINECS	Contact for details

Quality Control

Our Substance P (6-11), N(1,6)(β-Glucopyranosyl)Glu(5)-Pro(9)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency for critical research applications. All materials are subjected to comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.