Description

Trimethylacetamidomethylcysteine is a specialized, high-purity amino acid derivative with the CAS registry number 125700-47-2. This compound is a critical building block in advanced pharmaceutical synthesis, particularly for the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs). It is essential for research and production facilities in the pharmaceutical, biotechnology, and fine chemical sectors requiring precise molecular modifications and high-fidelity synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide drugs and proprietary APIs.
• Peptide Synthesis: Used as a protected cysteine derivative in solid-phase and solution-phase peptide chemistry to introduce specific functional groups.
• Bioconjugation: Serves as a linker or modifying agent for attaching payloads to proteins, antibodies, or other biomolecules in ADC (Antibody-Drug Conjugate) development.
• Proteomics Research: Employed in biochemical research for studying protein structure, function, and post-translational modifications.
• Chemical Biology Tool: Utilized to create probes and inhibitors for enzyme studies and target validation.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and custom organic molecules.

Basic Information

Product Name	Trimethylacetamidomethylcysteine
CAS No.	125700-47-2
Molecular Formula	C9H17N2O4S
Molecular Weight	249.31 g/mol
Synonyms	N-(Trimethylacetyl)-S-(amidomethyl)-L-cysteine; S-(Aminomethyl)-N-(2,2-dimethylpropanoyl)cysteine; L-Cysteine, S-(aminomethyl)-N-(2,2-dimethyl-1-oxopropyl)-; Acetamidomethylcysteine Trimethyl Derivative; TAM-Cysteine; Protected Cysteine Derivative; Cys(Acm) analog; Peptide Synthesis Building Block
EINECS	Contact for details

Quality Control

Every batch of Trimethylacetamidomethylcysteine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.