Description

n-(9-Fluorenylmethoxycarbonyl)Glycine-1-13C-15N is a high-purity, isotopically labeled derivative of the amino acid glycine, specifically enriched with stable isotopes Carbon-13 and Nitrogen-15 at the 1-position. This compound is critical for advanced research and development where precise molecular tracking and quantification are required. It is an essential building block for pharmaceutical and proteomic research, particularly in the synthesis of isotopically labeled peptides for mass spectrometry, metabolic studies, and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Isotope-Labeled Peptide Synthesis: A key precursor for the solid-phase synthesis of peptides containing stable isotope labels for use as internal standards in quantitative proteomics and biomarker discovery.
• Metabolic Pathway Tracing: Used in metabolic flux analysis and pharmacokinetic studies to track the incorporation and fate of glycine in biological systems.
• NMR Spectroscopy Standards: Serves as a reference standard for structural elucidation and dynamic studies of proteins and peptides due to its distinct 13C and 15N NMR signals.
• Pharmaceutical R&D: Employed in the development and quality control of peptide-based therapeutics, enabling precise analytical method development and validation.
• Mass Spectrometry (MS): Essential for creating heavy-labeled peptide standards used in MS-based absolute quantification (AQUA) strategies, improving accuracy and reproducibility.
• Biochemical Research: Used in studies of enzyme mechanisms, protein folding, and molecular interactions where isotopic labeling is necessary.

Basic Information

Product Name	n-(9-Fluorenylmethoxycarbonyl)Glycine-1-13C-15N
CAS No.	125700-33-6
Molecular Formula	C17H1413CN15O4
Molecular Weight	313.31 g/mol (for 13C15N labeled form)
Synonyms	Fmoc-Glycine-1-13C-15N; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine-1-13C-15N; Fmoc-Gly-OH-1-13C-15N; (9-Fluorenylmethyloxycarbonyl)glycine-1-13C-15N; N-Fmoc-glycine-1-13C-15N; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-13C-15N; Fmoc-13C15N-Gly-OH
EINECS	Contact for details

Quality Control

Our n-(9-Fluorenylmethoxycarbonyl)Glycine-1-13C-15N is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C and >99 atom % 15N), chemical purity by HPLC, and identity confirmation. We adhere to relevant guidelines for the production of stable isotope-labeled compounds for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
13C Isotopic Enrichment	≥99 atom %
15N Isotopic Enrichment	≥99 atom %
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.