Description

Ro 41-0960 is a potent and selective catechol-O-methyltransferase (COMT) inhibitor. This compound is a critical research tool for investigating the role of COMT in neurological pathways, particularly in the metabolism of catecholamine neurotransmitters like dopamine. It is primarily utilized by pharmaceutical researchers and academic institutions in the fields of neuroscience and drug discovery. The product is supplied under the CAS registry number 125628-97-9.

Application

• Neuroscience Research: Used as a standard COMT inhibitor to study the pharmacokinetics and pharmacodynamics of catecholamine neurotransmitters in preclinical models.
• Drug Discovery & Development: Serves as a reference compound for screening and developing new therapeutic agents targeting Parkinson's disease and other neurological disorders.
• Biochemical Assays: Employed in in vitro enzymatic assays to measure COMT activity and evaluate the efficacy of novel inhibitors.
• Metabolic Pathway Analysis: Aids in the investigation of metabolic pathways involving L-DOPA and endogenous catechol estrogens.
• Academic & Institutional Research: Essential for fundamental research in university and institutional laboratories focused on neurochemistry and neuropharmacology.

Basic Information

Product Name	Ro 41-0960
CAS No.	125628-97-9
Molecular Formula	C14H12N2O5
Molecular Weight	288.26 g/mol
Synonyms	3,5-Dinitrocatechol; 1,2-Dihydroxy-3,5-dinitrobenzene; 3,5-Dinitro-1,2-benzenediol; Ro-41-0960; Ro 410960; COMT Inhibitor I; CGP 28014
EINECS	Contact for details

Quality Control

Our Ro 41-0960 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.