Description

N4-Benzoyl-7'-Oh-n-Trityl Morpholino Cytosine is a sophisticated, high-purity nucleoside derivative specifically designed for advanced pharmaceutical research and synthesis. This compound serves as a critical protected intermediate in the synthesis of oligonucleotides and modified nucleic acids, enabling precise control over molecular structure. It is essential for researchers and manufacturers in the fields of antisense therapeutics, diagnostic probe development, and medicinal chemistry, where building block purity and reliability are paramount.

Application

• Oligonucleotide Synthesis: A key phosphoramidite or solid-phase synthesis building block for creating morpholino-based antisense oligonucleotides.
• Antisense Drug Development: Used in the research and production of therapeutic agents that modulate gene expression for treating genetic disorders, cancers, and viral infections.
• Diagnostic Probe Manufacture: Integral to the production of high-specificity probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Medicinal Chemistry & API Intermediates: Serves as a protected intermediate in the synthetic pathways of novel active pharmaceutical ingredients (APIs) targeting nucleic acid interactions.
• Biochemical Research: Employed in academic and industrial R&D for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• Custom Nucleic Acid Services: A vital raw material for CROs and CDMOs offering custom oligonucleotide synthesis services.

Basic Information

Product Name	N4-Benzoyl-7'-Oh-n-Trityl Morpholino Cytosine
CAS No.	125515-31-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7'-Hydroxy-N4-benzoyl-5'-O-trityl morpholino cytosine; N4-Benzoyl-5'-O-trityl-7'-hydroxy morpholino cytosine; 7'-OH-N4-Bz-5'-O-DMT Morpholino C; Bz-Morpholino-C(DMT) Phosphoramidite precursor; 2-N-Benzoyl-7-hydroxy-5'-O-(4,4'-dimethoxytrityl)morpholino cytosine; Protected Morpholino Cytosine monomer; PMO Cytosine building block
EINECS	Contact for details

Quality Control

Our N4-Benzoyl-7'-Oh-n-Trityl Morpholino Cytosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions, ideally in a desiccator or with appropriate desiccant in the primary container. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.