Description

T-Butyloxycarbonyltyrosyl-Glycyl-Glycyl-Phenylalanyl-Psi(Thioamide)Leucyl Benzyl Ester is a sophisticated, custom-designed peptide derivative featuring a thioamide backbone modification. This compound is a critical building block in advanced pharmaceutical research, particularly for developing protease inhibitors and studying enzyme-substrate interactions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, structurally complex intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel therapeutic peptides and peptidomimetics.
• Protease Inhibitor Research: The thioamide (Psi) moiety is strategically used to create stable transition-state analogs for studying protease mechanisms and designing inhibitors.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize the potency and metabolic stability of peptide-based drug candidates.
• Biochemical Tool: Acts as a specialized substrate or inhibitor in enzymatic assays to investigate specific biological pathways.
• Custom Peptide Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex, non-standard amino acid sequences.

Basic Information

Product Name	T-Butyloxycarbonyltyrosyl-Glycyl-Glycyl-Phenylalanyl-Psi(Thioamide)Leucyl Benzyl Ester
CAS No.	125482-08-8
Molecular Formula	C41H51N5O9S
Molecular Weight	790.0 g/mol (approx.)
Synonyms	Boc-Tyr-Gly-Gly-Phe-ψ[CS-NH]-Leu-OBzl; Boc-Tyr-Gly-Gly-Phe-ψ[Thioamide]-Leu-Benzyl Ester; t-Boc-Tyr-Gly-Gly-Phe-ψ(CSNH)Leu-OBzl; N-α-(tert-Butoxycarbonyl)-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-N-[(benzyloxy)carbonyl]-L-leucinethioamide; Peptide Thioamide Derivative; Protease Inhibitor Precursor
EINECS	Contact for details

Quality Control

This high-value peptide intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and structural integrity. Purity is typically verified by advanced chromatographic methods (HPLC, UPLC) and structural confirmation by mass spectrometry (MS) and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each batch to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.