Description

Gly-Arg-Ala-Asp-Ser-Pro-Lys is a synthetic heptapeptide sequence with the CAS registry number 125455-58-5. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a specific substrate or inhibitor for various proteolytic enzymes, including matrix metalloproteinases (MMPs). It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical development companies engaged in enzymology studies, drug discovery, and the development of therapeutic agents targeting protease-related pathways.

Application

• Biochemical Research: Used as a specific chromogenic or fluorogenic substrate for kinetic assays and inhibition studies of serine proteases and matrix metalloproteinases (MMPs).
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery and optimization of novel protease inhibitor drugs.
• Diagnostic Reagents: Incorporated into enzymatic assay kits for the detection and quantification of specific protease activity in clinical or research samples.
• Cell Biology Studies: Applied in research investigating cell adhesion, migration, and signaling pathways mediated by integrin recognition sequences (RGD motif present).
• Enzyme Characterization: Employed to determine enzyme specificity, catalytic efficiency (kcat/Km), and for the functional characterization of newly discovered proteases.
• Quality Control: Used as a purity reference standard in the production and quality assurance of related peptide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Gly-Arg-Ala-Asp-Ser-Pro-Lys
CAS No.	125455-58-5
Molecular Formula	C27H48N12O11
Molecular Weight	692.75 g/mol
Synonyms	GRADSPK; H-Gly-Arg-Ala-Asp-Ser-Pro-Lys-OH; Glycyl-arginyl-alanyl-aspartyl-seryl-prolyl-lysine; Heptapeptide GRADSPK; MMP Substrate Peptide; Protease Substrate VII; CAS 125455-58-5
EINECS	Contact for details

Quality Control

Our Gly-Arg-Ala-Asp-Ser-Pro-Lys is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA) to ensure structural integrity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.