Description

Cys(Acm)(2,7)-α-Calcitonin Gene-Related Peptide (Human) CAS NO 125448-83-1 is a chemically modified, protected form of the potent neuropeptide CGRP, specifically engineered for research and development applications. This derivative is critical for studying peptide structure-activity relationships, receptor binding, and for use as a key intermediate in the synthesis of complex peptide analogs. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, cardiovascular research, and migraine therapeutic development. The Acm (acetamidomethyl) protecting group on the cysteine residues provides stability and enables selective deprotection for controlled disulfide bond formation.

Application

• Pharmaceutical Research & Development: Serves as a crucial intermediate in the synthesis of novel CGRP analogs and peptide-based drug candidates targeting migraine, cardiovascular, and inflammatory pathways.
• Neuroscience Studies: Used in receptor binding assays, signal transduction research, and to investigate the physiological and pathological roles of CGRP in the central and peripheral nervous systems.
• Bioconjugation & Peptide Engineering: The protected cysteine residues allow for site-specific modifications, labeling, or conjugation to other molecules, carriers, or solid supports for advanced biochemical applications.
• Reference Standard: Acts as a high-purity analytical standard for quality control in peptide manufacturing and for method development in chromatographic (HPLC, LC-MS) analyses.
• Academic & Preclinical Research: Employed in university and institutional labs for fundamental research into peptide chemistry, hormone action, and vascular biology.

Basic Information

Product Name	Cys(Acm)(2,7)-α-Calcitonin Gene-Related Peptide (Human)
CAS No.	125448-83-1
Molecular Formula	C185H301N55O52S2
Molecular Weight	~4180.9 g/mol
Synonyms	α-CGRP (Human), Cys(Acm)(2,7)-α-CGRP; Calcitonin Gene-Related Peptide I, human, Cys(Acm)2,7-; [Cys(Acm)2,7]-α-CGRP; Protected α-CGRP; Acetamidomethyl-Cys(2,7)-α-CGRP; CGRP-I (2,7-Acm protected); h-α-CGRP (2,7-Acm)
EINECS	Contact for details

Quality Control

Our Cys(Acm)(2,7)-α-Calcitonin Gene-Related Peptide (Human) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and content. We adhere to stringent analytical protocols, and our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates and research biochemicals. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.