Description

Vasopressin, N,n-Diethylamide 1-(1-Mercaptocyclohexaneacetic Acid)-2-o-Methyl-Tyr-4-Glutamic Acid (γ-N,n-Diethylamide)-8-Arg- CAS NO 125443-55-2 is a synthetic, nonapeptide analog of vasopressin, engineered with specific modifications to enhance receptor selectivity and metabolic stability. This compound is of significant value for advanced pharmaceutical research and development, particularly in the study of vasopressin receptor subtypes and their physiological roles. It is primarily needed by biotech and pharmaceutical companies engaged in developing novel therapeutics for conditions related to fluid balance, cardiovascular function, and central nervous system disorders.

Application

• Pharmacological Research: A key tool for in vitro and in vivo studies targeting V1a, V1b, and V2 vasopressin receptors to elucidate signaling pathways and physiological effects.
• Drug Discovery & Development: Serves as a reference standard or lead compound in the design of new peptide-based therapeutics for diabetes insipidus, septic shock, and hypertension.
• Biochemical Assay Development: Used in the development and validation of high-throughput screening (HTS) assays and radioimmunoassays (RIA) for receptor binding studies.
• Neuroscience Research: Investigates the role of vasopressin in social behavior, stress response, memory, and autonomic regulation within the central nervous system.
• Preclinical Studies: Employed in animal models to evaluate the efficacy, pharmacokinetics, and safety profile of vasopressin-related drug candidates.
• Chemical Synthesis Intermediate: Acts as a sophisticated building block for the synthesis of further modified peptide analogs with tailored properties.

Basic Information

Product Name	Vasopressin, N,n-Diethylamide 1-(1-Mercaptocyclohexaneacetic Acid)-2-o-Methyl-Tyr-4-Glutamic Acid (γ-N,n-Diethylamide)-8-Arg-
CAS No.	125443-55-2
Molecular Formula	C52H84N14O12S
Molecular Weight	1081.4 g/mol
Synonyms	d(CH2)5[Tyr(Me)^2, Lys(Nε-NEt2)^4, Arg^8]Vasopressin; SK&F 105494; [1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-O-methyltyrosine, 4-lysine(Nε-diethylamide), 8-arginine]vasopressin; V1a Vasopressin Receptor Antagonist; Manning Compound; d(CH2)5[Tyr(Me)^2, Dab(Nδ-NEt2)^4, Arg^8]VP; Desmopressin Analog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request. We adhere to a cGMP-compliant quality management system to ensure traceability and consistency for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.