Description

Acetyl-Hirudin (55-65) (Sulfated) is a chemically modified, potent and specific thrombin inhibitor derived from the natural anticoagulant hirudin. This product is critical for researchers and developers in the life sciences sector requiring a highly stable and active antithrombotic agent for experimental and therapeutic applications. Its primary value lies in its enhanced stability and targeted activity, making it indispensable for advanced biochemical research, diagnostic assay development, and novel anticoagulant drug discovery.

Application

• Biochemical Research: Used as a specific tool to study thrombin's role in coagulation cascades, cell signaling, and inflammatory processes.
• Diagnostic Reagent Development: Serves as a key component in the formulation of precise in-vitro diagnostic kits for measuring thrombin activity or clotting times.
• Pharmaceutical R&D: Acts as a reference standard or active pharmaceutical ingredient (API) in the development of next-generation antithrombotic and antiplatelet therapies.
• Medical Device Coating: Employed to create biocompatible, non-thrombogenic surfaces on stents, catheters, and other blood-contacting medical implants.
• Protease Inhibition Studies: Provides a model for studying serine protease inhibition mechanisms and structure-activity relationships (SAR).

Basic Information

Product Name	Acetyl-Hirudin (55-65) (Sulfated)
CAS No.	125441-01-2
Molecular Formula	C284H439N83O110S27 (Representative)
Molecular Weight	~7000 g/mol (Approximate)
Synonyms	Acetylhirudin; N-Acetylhirudin; Hirudin, N-acetyl-; Acetylated Hirudin; Sulfated Hirudin Fragment (55-65); Thrombin Inhibitor (Acetylated); Anticoagulant Peptide; r-Hirudin variant
EINECS	Contact for details

Quality Control

Our Acetyl-Hirudin (55-65) (Sulfated) is manufactured under stringent controls to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical methods including HPLC for purity, peptide mapping for sequence confirmation, and functional activity assays. A Certificate of Analysis (COA) detailing purity, potency, and endotoxin levels is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Biological Activity	≥ 12,000 ATU/mg
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.