Description

(tert-Butoxy)Carbonyl α-Methylthyl-D-Propargylglycine is a specialized, high-purity amino acid derivative designed for advanced pharmaceutical synthesis and research. This compound serves as a critical chiral building block, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for peptide-mimetics and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a propargylglycine moiety with a protected α-amino group (Boc-protected) for click chemistry applications or structural diversification.
• Chemical Biology & Proteomics: Acts as a metabolic labeling agent or a building block for activity-based probes, leveraging the alkyne handle for bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of non-natural, sterically constrained amino acids on the biological activity of lead compounds.
• Asymmetric Synthesis: Serves as a valuable starting material or auxiliary in catalytic asymmetric transformations due to its defined D-configuration and protected functional groups.
• Fine Chemical Production: Used in the custom synthesis of complex organic molecules for agrochemicals, advanced materials, and specialty chemicals.

Basic Information

Product Name	(tert-Butoxy)Carbonyl α-Methylthyl-D-Propargylglycine
CAS No.	125414-56-4
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	Boc-D-Propargylglycine; Boc-D-2-amino-4-pentynoic acid; (2R)-2-[(tert-Butoxycarbonyl)amino]-4-pentynoic acid; N-(tert-Butoxycarbonyl)-D-propargylglycine; D-Boc-Propargylglycine; N-Boc-D-2-amino-4-pentynoic acid; tert-Butyl (R)-(1-carboxy-3-butyn-1-yl)carbamate; D-2-(Boc-amino)pent-4-ynoic acid
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl α-Methylthyl-D-Propargylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.