Description

3-(R)-3-Hydroxy-Prazepam is a key chiral metabolite and synthetic intermediate of the benzodiazepine class. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism and the synthesis of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) therapeutics and analytical reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the analytical quantification of prazepam and its metabolites in bioanalytical studies.
• Metabolite Research: Used in pharmacokinetic and pharmacodynamic research to understand the metabolic pathway and activity of the parent drug, prazepam.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a chiral building block or intermediate in the sophisticated synthesis of benzodiazepine-derived pharmaceuticals.
• Forensic and Clinical Toxicology: Employed as an analytical standard in laboratories for the accurate detection and confirmation of benzodiazepine use in forensic and clinical samples.
• Biochemical Research: Utilized in studies investigating the mechanism of action of GABA-A receptor modulators.

Basic Information

Product Name	3-(R)-3-Hydroxy-Prazepam
CAS No.	125299-89-0
Molecular Formula	C19H17ClN2O2
Molecular Weight	340.80 g/mol
Synonyms	(R)-3-Hydroxyprazepam; 3R-Hydroxy Prazepam; 7-Chloro-1-(cyclopropylmethyl)-3R-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Prazepam Metabolite (3R-Hydroxy); 1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-3R-hydroxy-5-phenyl-; (R)-7-Chloro-1-(cyclopropylmethyl)-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our 3-(R)-3-Hydroxy-Prazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.