Description

Fmoc-Dab(Boc)-Oh CAS NO 125238-99-5 is a high-purity, orthogonally protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound provides critical protection for the side chain of diaminobutyric acid (Dab), enabling the precise and sequential construction of complex peptides. It is a fundamental building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, used in automated peptide synthesizers.
• Pharmaceutical R&D: Building block for the synthesis of novel therapeutic peptides targeting various diseases.
• Bioconjugation: Used to introduce a selectively deprotectable amino group for linking peptides to other molecules, proteins, or surfaces.
• Peptidomimetic Design: Incorporation into non-natural peptide analogs to enhance stability, bioavailability, or activity.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening of bioactive compounds.
• Academic Research: Fundamental reagent for studying protein structure-function relationships and enzyme mechanisms.

Basic Information

Item	Detail
Product Name	Fmoc-Dab(Boc)-Oh
CAS No.	125238-99-5
Molecular Formula	C25H30N2O6
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-L-2,4-diaminobutyric acid(Boc)-OH; Nα-Fmoc-Nγ-Boc-L-2,4-diaminobutyric acid; Fmoc-Dab(Boc)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid; Fmoc-L-Dab(Boc)-OH; Nα-Fmoc-Nω-Boc-L-α,γ-diaminobutyric acid; Fmoc-4-(Boc-amino)-L-homoalanine; Boc-Dab(Fmoc)-OH (isomer)
EINECS	Contact for details

Quality Control

Our Fmoc-Dab(Boc)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements of peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and supply reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.