Description

(p-Chloro-Phe5,8)-Bradykinin CAS NO 125229-63-2 is a synthetic, site-specifically modified peptide analog of the endogenous vasoactive peptide bradykinin. This modification, incorporating chlorine at specific phenylalanine residues, is designed to enhance receptor binding affinity and metabolic stability for advanced research applications. It is a critical tool for researchers in pharmacology, cardiovascular studies, and drug discovery, particularly for investigating the bradykinin B2 receptor pathway and developing novel therapeutic agents.

Application

• Pharmacological Research: Used as a high-potency, stabilized agonist/antagonist reference standard for studying the bradykinin B2 receptor signaling pathway.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the design of novel anti-inflammatory, analgesic, or cardiovascular drugs.
• Biochemical Assays: Employed in in vitro and cell-based assays to measure receptor activation, ligand binding affinity (Ki/IC50), and intracellular calcium mobilization.
• Academic & Institutional Research: Essential for fundamental studies in vascular biology, pain mechanisms, and inflammatory responses.
• Peptide Chemistry Studies: Used as a model compound for investigating structure-activity relationships (SAR) of modified bradykinin analogs.

Basic Information

Product Name	(p-Chloro-Phe5,8)-Bradykinin
CAS No.	125229-63-2
Molecular Formula	C50H68Cl2N14O11
Molecular Weight	1088.06 g/mol
Synonyms	Bradykinin, [Phe5(p-Cl),Phe8(p-Cl)]-; [p-Chloro-Phe5,8]-Bradykinin; [Phe5(4-Cl),Phe8(4-Cl)]-Bradykinin; H-Arg-Pro-Pro-Gly-Phe(4-Cl)-Ser-Pro-Phe(4-Cl)-Arg-OH; (pCl-Phe5,8)-BK; Chlorinated Bradykinin Analog; B2 Receptor Selective Analog
EINECS	Contact for details

Quality Control

Our (p-Chloro-Phe5,8)-Bradykinin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability, batch-to-batch consistency, and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.