Description

Polyphemusin Ii CAS NO 125139-68-6 is a synthetic, cationic antimicrobial peptide (AMP) derived from the horseshoe crab. This compound is of significant interest for its potent biological activity, particularly its ability to inhibit viral and bacterial growth by disrupting cell membranes. It serves as a critical research tool and a promising lead compound for the development of novel anti-infective agents and therapeutic peptides. Key target industries include pharmaceutical R&D, biotechnology, and academic research focused on immunology, virology, and antimicrobial drug discovery.

Application

• Antiviral Research: Investigation of its mechanism of action against enveloped viruses, including HIV, as a potential therapeutic agent.
• Antimicrobial Development: Serving as a structural template for designing new synthetic peptides with enhanced activity against drug-resistant bacteria.
• Biochemical Studies: Used in studies of peptide-membrane interactions, pore formation, and cell lysis mechanisms.
• Immunology Research: Exploring its role as a host defense peptide and its immunomodulatory properties.
• Pharmaceutical Lead Optimization: As a starting point for medicinal chemistry programs aimed at improving pharmacokinetic properties and reducing toxicity.
• Diagnostic Reagent Component: Potential use in assays designed to detect microbial contamination or study membrane integrity.

Basic Information

Product Name	Polyphemusin Ii
CAS No.	125139-68-6
Molecular Formula	C95H147N31O23
Molecular Weight	2124.4 g/mol
Synonyms	Polyphemusin II; Tachyplesin I (analog); Antimicrobial peptide Polyphemusin-II; Tachyplesin-like peptide; Horseshoe crab antimicrobial peptide; Arg-rich antimicrobial peptide; HIV inhibitor peptide; CAS 125139-68-6
EINECS	Contact for details

Quality Control

Our Polyphemusin Ii is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide full traceability and documentation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.