Description

Polyphemusin I is a synthetic, cationic antimicrobial peptide (AMP) derived from the natural peptide found in horseshoe crab hemocytes. This compound is of significant interest for its potent, broad-spectrum activity against bacteria, fungi, and enveloped viruses, functioning by disrupting microbial cell membranes. It serves as a critical research tool and a promising lead compound for pharmaceutical development, particularly in the fields of antimicrobial drug discovery, biomaterials coating, and immunology research.

Application

• Antimicrobial Research & Drug Development: As a model peptide for studying membrane-disrupting mechanisms and developing novel anti-infective agents.
• Biomaterial & Medical Device Coatings: Used to create antimicrobial surfaces for implants, catheters, and wound dressings to prevent biofilm formation.
• Virology Studies: Investigation of its activity against enveloped viruses (e.g., HIV, HSV) for potential therapeutic applications.
• Immunology & Innate Immunity Research: Study of host defense peptides and their role in the innate immune response.
• Biochemical Reagent: Used in laboratory assays to study peptide-lipid interactions and membrane permeability.
• Cosmetic & Personal Care Formulations: Exploration as a natural preservative or active ingredient in products requiring antimicrobial protection.

Basic Information

Product Name	Polyphemusin I
CAS No.	125139-67-5
Molecular Formula	C95H147N31O25S2
Molecular Weight	2188.5 g/mol
Synonyms	Polyphemusin-I; Tachyplesin I-derived peptide; Antimicrobial peptide Polyphemusin I; Arg-rich antimicrobial peptide; Tachyplesin I analog; Horseshoe crab peptide; HcPeptide1; CAS 125139-67-5
EINECS	Contact for details

Quality Control

Our Polyphemusin I is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to rigorous analytical standards, utilizing HPLC, MS, and amino acid analysis to verify product integrity and meet the specific requirements of pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.