Description

4-Chloro-8-Iodoquinazoline is a halogenated quinazoline derivative, a versatile and highly functionalized heterocyclic building block. Its core value lies in its dual halogen substituents, which provide distinct reactive sites for selective cross-coupling and nucleophilic substitution reactions, enabling the synthesis of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other biologically active quinazoline-based compounds for oncology and other therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the quinazoline scaffold's bioactivity.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution to introduce diverse functional groups.
• Academic & R&D: A valuable reagent for medicinal chemistry programs and methodological studies in organic synthesis within university and corporate research laboratories.

Basic Information

Product Name	4-Chloro-8-Iodoquinazoline
CAS No.	125096-73-3
Molecular Formula	C8H4ClIN2
Molecular Weight	290.49 g/mol
Synonyms	8-Iodo-4-chloroquinazoline; 4-Chloro-8-iodoquinazoline; Quinazoline, 4-chloro-8-iodo-; 125096-73-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Iodoquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.