Description

Fmoc-Tyr(Tbu)-Opfp is a high-purity, protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and controlled assembly of complex peptides and proteins in research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of medicinal chemistry, bioconjugation, and proteomics who require reliable, high-quality reagents for advanced peptide synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected tyrosine derivative for the sequential construction of peptide chains on resin.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Acts as a reagent for introducing tyrosine residues into biomolecules for labeling or cross-linking studies.
• Combinatorial Library Synthesis: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Proteomics Research: Utilized in the synthesis of defined peptide sequences for use as standards, antigens, or probes.
• Custom Peptide Production: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	Fmoc-Tyr(Tbu)-Opfp
CAS No.	125043-03-0
Molecular Formula	C30H28F5NO5
Molecular Weight	577.55 g/mol
Synonyms	Fmoc-O-tert-butyl-L-tyrosine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine pentafluorophenyl ester; Fmoc-Tyr(OtBu)-OPfp; Fmoc-L-Tyrosine(O-t-butyl)-OPfp Ester; Fmoc-Tyr(tBu)-OPfp; Fmoc-Tyr(OtBu)-OPfp Ester; Nα-Fmoc-O-tert-butyl-L-tyrosine pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Tbu)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.