Description

Big Et-1 (22-38) (Human) is a synthetic peptide fragment corresponding to a specific region of the human endothelin-1 protein. This high-purity biochemical is critical for research into cardiovascular physiology, vascular tone regulation, and related disease mechanisms. It is an essential tool for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on endothelin receptor studies, assay development, and drug discovery programs. The compound is supplied with full analytical characterization to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: Used as a standard or reference material in studies investigating the role of endothelin-1 in hypertension, heart failure, and pulmonary arterial hypertension.
• Pharmacology & Drug Discovery: Serves as a key ligand for screening, characterizing, and validating potential endothelin receptor antagonists in high-throughput assays.
• Assay Development: Essential for the development and calibration of ELISA, RIA, and other immunoassays designed to detect endothelin-1 or its fragments.
• Cell Signaling Studies: Applied in vitro to stimulate endothelin receptors on vascular smooth muscle cells and other target tissues to study downstream signaling pathways.
• Biochemical Reagent: Utilized in structural biology and biophysical studies to understand peptide-receptor interactions.

Basic Information

Product Name	Big Et-1 (22-38) (Human)
CAS No.	124932-61-2
Molecular Formula	C86H130N24O23S2
Molecular Weight	1916.2 g/mol
Synonyms	Endothelin-1 (22-38) (human); ET-1 (22-38); Big Endothelin-1 (22-38) fragment; [Cys1, Cys15]-Endothelin-1 (22-38); H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bridge: Cys1-Cys15); Human Big ET-1 (22-38) peptide
EINECS	Contact for details

Quality Control

Every batch of Big Et-1 (22-38) (Human) is manufactured and analyzed under strict quality management systems. Identity and purity are verified by multiple orthogonal methods including HPLC and Mass Spectrometry. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical results. Our quality commitment ensures the material meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical composition
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.