Description

Big Endothelin 39 Bovine is a synthetic peptide fragment corresponding to the C-terminal sequence of the potent vasoconstrictor endothelin-1. This high-purity biochemical is essential for cardiovascular and pharmacological research, serving as a critical reference standard and tool compound. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors for studying endothelin receptor interactions, signal transduction pathways, and developing novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard in studies of endothelin biology, receptor binding assays, and vascular physiology.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the research and quality control of endothelin-related drug candidates.
• Cell Signaling Studies: Employed to investigate the role of endothelin in cellular processes, including vasoconstriction, cell proliferation, and hormone secretion.
• Diagnostic Reagent Manufacturing: Utilized in the production of calibration standards for immunoassay kits targeting endothelin peptides.
• Academic & Institutional Research: A vital tool for universities and research institutes conducting fundamental studies on cardiovascular diseases and peptide hormones.

Basic Information

Product Name	Big Endothelin 39 Bovine
CAS No.	124834-83-9
Molecular Formula	C198H302N56O57S5
Molecular Weight	~4365.8 g/mol
Synonyms	Endothelin-1 (39-77), bovine; Big ET-1 (39-77); Big Endothelin-1 (39-77), bovine; Proendothelin-1 (39-77); ET-1 (39-77); Big ET; Big Endothelin Fragment; H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge: Cys1-Cys15)
EINECS	Contact for details

Quality Control

Our Big Endothelin 39 Bovine is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for peptide synthesis, and our quality system is designed to meet the rigorous demands of pharmaceutical and analytical reference standard users.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.