Description

4-(2-(1,1'-Biphenyl)-4-Ylethoxy)-8-Fluoroquinazoline is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its core value lies in its role as a critical building block for the synthesis of novel, biologically active compounds, particularly in oncology and targeted therapy development. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug discovery programs. The CAS number for this product is 124428-19-9.

Application

This specialized quinazoline derivative serves as a key precursor in several high-value chemical synthesis pathways.

• Pharmaceutical Intermediate: Primary use in the synthesis of tyrosine kinase inhibitor (TKI) candidates and other targeted small-molecule therapeutics.
• Oncology Drug Discovery: A crucial scaffold for developing novel anti-cancer agents that interfere with specific cellular signaling pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of drug leads.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for process development and GMP manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Can be utilized in biochemical assays to study enzyme inhibition and mechanism of action.
• Custom Synthesis: Basis for the custom manufacturing of fluorinated quinazoline derivatives for specific client research projects.

Basic Information

Product Name	4-(2-(1,1'-Biphenyl)-4-Ylethoxy)-8-Fluoroquinazoline
CAS No.	124428-19-9
Molecular Formula	C22H17FN2O
Molecular Weight	344.38 g/mol
Synonyms	8-Fluoro-4-[2-(4-phenylphenyl)ethoxy]quinazoline; 4-[2-([1,1'-Biphenyl]-4-yl)ethoxy]-8-fluoroquinazoline; Biphenyl-4-ylethoxy-8-fluoroquinazoline; 124428-19-9; 8-Fluoro-4-(2-(biphenyl-4-yl)ethoxy)quinazoline; 4-(2-(Biphenyl-4-yl)ethoxy)-8-fluoroquinazoline; Quinazoline, 4-[2-([1,1'-biphenyl]-4-yl)ethoxy]-8-fluoro-
EINECS	Contact for details

Quality Control

Our 4-(2-(1,1'-Biphenyl)-4-Ylethoxy)-8-Fluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity intermediates for pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.