Description

Panadiplon is a high-purity, non-benzodiazepine anxiolytic agent belonging to the pyrazolopyrimidine class. This compound is of significant interest in pharmaceutical research and development due to its selective action on GABA-A receptors. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience studies and the development of novel central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Neuroscience Research: Used as a potent tool compound in preclinical studies to investigate the pharmacology of GABA-A receptor subtypes and their role in anxiety and related disorders.
• Drug Discovery & Development: Acts as a key intermediate or active pharmaceutical ingredient (API) in the synthesis and development of new anxiolytic and sedative-hypnotic drug candidates.
• Metabolite Studies: Employed in the identification and quantification of metabolites during pharmacokinetic and ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro binding assays to evaluate the activity of new chemical entities on GABAergic systems.

Basic Information

Product Name	Panadiplon
CAS No.	124423-84-3
Molecular Formula	C₁₉H₁₇FN₄O₂
Molecular Weight	352.36 g/mol
Synonyms	Panadiplon; U-78875; 7-Isopropoxy-2-(4-fluorophenyl)-3-methylpyrazolo[1,5-a]pyrimidine; 7-(1-Methylethoxy)-2-(4-fluorophenyl)-3-methylpyrazolo[1,5-a]pyrimidine; 2-(4-Fluorophenyl)-3-methyl-7-(propan-2-yloxy)pyrazolo[1,5-a]pyrimidine; U 78875; U78875
EINECS	Contact for details

Quality Control

Our Panadiplon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.