Description

4-Chloro-6-(4-Nitrophenoxy)Pyrimidine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive chloropyrimidine group and a nitrophenoxy moiety, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, serving as a key intermediate for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging its heterocyclic core.
• Material Science Research: Serves as a building block for creating functional organic materials, such as ligands for metal-organic frameworks (MOFs) or organic electronic components.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The chloro and nitrophenoxy groups provide handles for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Nucleophilic Aromatic Substitution: The chloropyrimidine is an excellent electrophile for substitution with various nucleophiles, enabling rapid diversification of molecular scaffolds.

Basic Information

Product Name	4-Chloro-6-(4-Nitrophenoxy)Pyrimidine
CAS No.	124041-03-8
Molecular Formula	C10H6ClN3O3
Molecular Weight	251.63 g/mol
Synonyms	4-Chloro-6-(4-nitrophenoxy)pyrimidine; 6-(4-Nitrophenoxy)-4-chloropyrimidine; 4-Chloro-6-(p-nitrophenoxy)pyrimidine; Pyrimidine, 4-chloro-6-(4-nitrophenoxy)-; 4-Chloro-6-(4-nitro-phenoxy)-pyrimidine; 4-Chloro-6-(4-nitro-phenoxy)pyrimidine; 4-Chloro-6-(4-nitrophenoxy)pyrimidine (CAS 124041-03-8)
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(4-Nitrophenoxy)Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.