Description

Prolyl-Leucyl-Alanine Hydroxamic Acid is a synthetic peptide hydroxamate derivative designed for advanced biochemical research and development. This compound is valued for its role as a potent and selective inhibitor of specific metalloproteases, making it a critical tool for studying enzymatic pathways and disease mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery, proteomics, and enzyme kinetics studies.

Application

• Biochemical Research: Serves as a reference standard and active inhibitor in enzymatic assays to study the function and inhibition of zinc-dependent metalloproteases.
• Drug Discovery & Development: Used as a lead compound or pharmacophore model in the design and screening of novel therapeutic agents targeting conditions like cancer, inflammation, and fibrosis.
• Proteomics & Cell Biology: Employed to modulate specific protease activity in cell culture and tissue studies to elucidate protein function and signaling pathways.
• Academic Research: A key reagent for universities and research institutes investigating enzyme structure-activity relationships and inhibitor design.
• Diagnostic Development: Potential use in the development of diagnostic kits and assays that require specific enzyme inhibition for detection.

Basic Information

Product Name	Prolyl-Leucyl-Alanine Hydroxamic Acid
CAS No.	123984-21-4
Molecular Formula	C17H30N4O5
Molecular Weight	370.45 g/mol
Synonyms	Pro-Leu-Ala-NHOH; H-Pro-Leu-Ala-NHOH; PLA-NHOH; Prolyl-Leucyl-Alanine Hydroxamate; N-(2-((2S)-1-((2S)-2-((2S)-2-(Hydroxycarbamoyl)pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-methyl-2-oxoethyl)pyrrolidine-2-carboxamide; (2S)-1-[(2S)-2-[(2S)-2-(Hydroxyamino)-2-oxoethyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide; Peptide Hydroxamic Acid Inhibitor
EINECS	Contact for details

Quality Control

Our Prolyl-Leucyl-Alanine Hydroxamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry (MS) and infrared (IR) spectroscopy, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.