Description

2,4-Difluoro-3-(trifluoromethyl)aniline is a high-purity fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoro and trifluoromethyl substituents, imparts significant electronic and steric properties, making it invaluable for creating molecules with enhanced metabolic stability and lipophilicity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, enhancing electronic properties and device performance.
• Functional Polymer Monomer: Incorporated into specialty polymers to modify thermal stability, chemical resistance, and surface properties for high-performance coatings and engineering plastics.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in cross-coupling reactions, amination, and other transformations involving fluorinated aromatics.
• Dye & Pigment Intermediate: Utilized in the synthesis of novel fluorinated dyes and pigments that offer superior lightfastness and color properties.

Basic Information

Product Name	2,4-Difluoro-3-(trifluoromethyl)aniline
CAS No.	123973-26-2
Molecular Formula	C7H4F5N
Molecular Weight	197.11 g/mol
Synonyms	3-(Trifluoromethyl)-2,4-difluoroaniline; 2,4-Difluoro-3-(trifluoromethyl)benzenamine; 2,4-Difluoro-alpha,alpha,α-trifluoro-m-toluidine; Benzenamine, 2,4-difluoro-3-(trifluoromethyl)-; 2,4-Difluoro-3-trifluoromethylaniline; 2,4-Difluoro-3-trifluoromethylphenylamine; 3-Amino-2,4-difluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-3-(trifluoromethyl)aniline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and we support custom specifications for cGMP or other regulated workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (Area %)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.