Description

4-Amino-2,6-Difluorobenzotrifluoride is a high-purity fluorinated aromatic amine building block of significant commercial importance. This compound is valued for its unique trifluoromethyl and amino functional groups, which impart specific electronic and steric properties critical for advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Employed in the production of high-performance, light-fast fluorinated dyes and pigments.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing complex molecular architectures.

Basic Information

Product Name	4-Amino-2,6-Difluorobenzotrifluoride
CAS No.	123950-44-7
Molecular Formula	C7H4F5N
Molecular Weight	197.11 g/mol
Synonyms	2,6-Difluoro-4-(trifluoromethyl)aniline; 4-Amino-2,6-difluoro-α,α,α-trifluorotoluene; 2,6-Difluoro-α,α,α-trifluoro-p-toluidine; 4-(Trifluoromethyl)-2,6-difluoroaniline; 2,6-Difluoro-4-trifluoromethylaniline; 4-Amino-2,6-difluorobenzotrifluoride; Benzenamine, 2,6-difluoro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Amino-2,6-Difluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.