Description

H-Leu-Val-4Mβna · Hcl is a specialized peptide derivative, specifically a dipeptide substrate linked to a 4-methoxy-β-naphthylamide fluorogenic group. This compound is of significant value in biochemical and pharmaceutical research as a highly sensitive and specific substrate for various proteolytic enzymes. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in enzyme kinetics studies, protease activity assays, and high-throughput screening for drug discovery.

Application

• Protease/Enzyme Assays: As a fluorogenic substrate for quantifying the activity of specific proteases like dipeptidyl peptidases (DPP) and other serine or cysteine proteases in research settings.
• Biochemical Research: For studying enzyme kinetics, inhibition mechanisms, and substrate specificity in academic and industrial laboratories.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) platforms to identify and characterize potential therapeutic enzyme inhibitors.
• Diagnostic Development: A key component in developing sensitive fluorometric diagnostic assays for clinical and research purposes.
• Cell Biology Studies: Used to detect and localize protease activity within live cells or tissue samples.

Basic Information

Product Name	H-Leu-Val-4Mβna · Hcl
CAS No.	123825-03-6
Molecular Formula	C23H34N4O4 · HCl
Molecular Weight	474.99 g/mol (for free base C23H34N4O4>)
Synonyms	L-Leucyl-L-valine 4-methoxy-β-naphthylamide hydrochloride; H-Leu-Val-4-Methoxy-β-NA · HCl; Leu-Val-4MβNA hydrochloride; 4-Methoxy-2-naphthylamide of L-leucyl-L-valine; Fluorogenic substrate for DPP-IV; DPP-IV Substrate (Leu-Val); Val-Leu-4-Methoxy-β-naphthylamide (sequence variant); Peptide substrate 4Mβna
EINECS	Contact for details

Quality Control

Our H-Leu-Val-4Mβna · Hcl is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, desiccate at low temperature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.