Description

Bombesin (6-14), Nal(6)-Psi(13,14)-Phe(14)- is a synthetic peptide analog of the neuropeptide bombesin, specifically engineered with modifications at positions 6, 13, and 14. This compound is of significant interest for its role as a potent and selective ligand for bombesin receptor subtypes, particularly in advanced biochemical research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers investigating receptor biology, cancer therapeutics, and neuroendocrine signaling pathways.

Application

• Biochemical Research: Used as a high-affinity, selective probe for studying bombesin receptor (BB1, BB2, BB3) binding, activation, and internalization mechanisms.
• Oncology Research: Serves as a critical tool in preclinical studies targeting bombesin receptor-positive cancers, such as prostate, breast, and small-cell lung carcinoma, for imaging and therapeutic development.
• Neuroscience Studies: Applied in research on neuropeptide signaling, synaptic transmission, and the role of bombesin-like peptides in feeding behavior and stress responses.
• Diagnostic Agent Development: Acts as a precursor or reference standard in the development of radiolabeled (e.g., with 68Ga, 177Lu) peptides for positron emission tomography (PET) imaging and targeted radiotherapy.
• Pharmacology & Drug Discovery: Employed in high-throughput screening (HTS) assays and structure-activity relationship (SAR) studies to design novel receptor agonists or antagonists.
• Cell Biology: Used to stimulate receptor-mediated cellular processes, including calcium mobilization and mitogen-activated protein kinase (MAPK) pathway activation, in vitro.

Basic Information

Product Name	Bombesin (6-14), Nal(6)-Psi(13,14)-Phe(14)-
CAS No.	123770-00-3
Molecular Formula	C65H92N18O14
Molecular Weight	1301.5 g/mol (theoretical)
Synonyms	[D-Phe6, Des-Met14]Bombesin(6-14) ethylamide; Nal(6)-Psi(13,14)-Phe(14)-Bombesin(6-14); Bombesin (6-14) analog; BBN(6-14) analog; [D-Phe6, Leu13 psi(CH2NH)Leu14]Bombesin(6-14); Bombesin receptor ligand; GRP receptor antagonist analog; Pseudopeptide bombesin analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and controlled under a strict quality management system. Each batch of Bombesin (6-14), Nal(6)-Psi(13,14)-Phe(14)- undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis to specific purity levels (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in DMSO, acetic acid solution; sparingly soluble in water
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.