Description

14-Carboxy-13-cis-Retinamide-Sepharose 4B is a specialized affinity chromatography medium designed for the selective purification and study of retinoic acid-binding proteins and receptors. This product is critical for researchers and manufacturers requiring high-purity protein isolates for structural analysis, drug discovery, and biochemical assay development. It is primarily utilized in the pharmaceutical, biotechnology, and life sciences research sectors for targeted protein separation and biomarker research.

Application

• Affinity Chromatography: Primary tool for the selective isolation and purification of cellular retinoic acid-binding proteins (CRABPs) and nuclear retinoic acid receptors (RARs, RXRs).
• Drug Discovery Research: Used in screening assays to identify and characterize novel ligands and inhibitors that interact with retinoid signaling pathways.
• Proteomics and Biomarker Studies: Enables the capture and enrichment of specific retinoid-binding proteins from complex biological samples for downstream mass spectrometry analysis.
• Enzyme and Protein Characterization: Supports the study of protein-ligand interactions, binding kinetics, and structural biology of retinoid-associated proteins.
• Biopharmaceutical Production: Can be integrated into purification workflows for recombinant proteins involved in retinoid metabolism or signaling.
• Diagnostic Development: Potential use in developing diagnostic tools and assays that measure retinoid-binding protein levels in clinical samples.

Basic Information

Product Name	14-Carboxy-13-cis-Retinamide-Sepharose 4B
CAS No.	123757-90-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	13-cis-Retinoic Acid-Sepharose 4B; Retinamide-Sepharose 4B; 13-cis-Retinamide Affinity Gel; Sepharose 4B-linked 14-Carboxy-13-cis-Retinamide; CRABP Affinity Medium; Retinoic Acid Receptor Affinity Resin; 13-cis-RA-Sepharose CL-4B; N-(Retinoyl)-Sepharose 4B
EINECS	Contact for details

Quality Control

Our 14-Carboxy-13-cis-Retinamide-Sepharose 4B is produced under stringent quality management protocols. Each batch is tested for ligand density, binding capacity, and matrix integrity to ensure consistent and reliable performance. Certificates of Analysis (COA) detailing specific lot parameters are available upon request to support your research and quality assurance documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in the supplied storage solution (typically 20% ethanol) to prevent microbial growth and maintain ligand stability. Do not freeze. The product is light-sensitive; prolonged exposure to light should be avoided during handling.

Specification

Item	Specification
Matrix	Sepharose 4B
Ligand	14-Carboxy-13-cis-Retinamide
Ligand Density	Contact for details
Binding Capacity	Contact for details
Particle Size	45-165 μm
Maximum Flow Pressure	0.3 MPa, 3 bar
pH Stability	3 - 12 (long term), 2 - 14 (short term)
Storage Solution	20% Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.