Description

Atrial Natriuretic Factor (3-28) is a bioactive peptide fragment derived from the N-terminus of the atrial natriuretic peptide (ANP) hormone. This specific sequence is critical for research into cardiovascular physiology and renal function regulation. It serves as a valuable reference standard and research tool for scientists and pharmaceutical developers. Primary users include biochemical research laboratories, academic institutions, and pharmaceutical companies focused on cardiovascular drug discovery and diagnostic assay development.

Application

• Biochemical Research: Used as a reference standard in studies investigating the structure-activity relationship (SAR) of atrial natriuretic peptides.
• Cardiovascular Pharmacology: Employed in in vitro and in vivo assays to study mechanisms of vasodilation, blood pressure regulation, and natriuresis.
• Diagnostic Development: Acts as a critical antigen or calibrator in the development of immunoassays (e.g., ELISA) for detecting ANP-related biomarkers.
• Receptor Binding Studies: Utilized to characterize and quantify binding affinity to natriuretic peptide receptors (NPR-A, NPR-C) in competitive binding assays.
• Enzyme Activity Assays: Serves as a substrate for studying the activity and inhibition of proteolytic enzymes like neprilysin that degrade ANP.
• Pharmaceutical Quality Control: Functions as a system suitability standard in analytical methods for peptide-based drug candidates targeting the ANP pathway.

Basic Information

Product Name	Atrial Natriuretic Factor (3-28)
CAS No.	123748-55-0
Molecular Formula	C119H190N40O39
Molecular Weight	~2652.0 g/mol
Synonyms	ANF (3-28); Atrial Natriuretic Peptide (3-28); ANP (3-28); Cardionatrin (3-28); Atriopeptin (3-28); rANP (3-28); Ser103-Tyr126 Atrial Natriuretic Factor; H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (3-28) is produced and tested under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and Mass Spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.