Description

2,6-Dimethyl-L-Tyrosine is a non-natural, sterically hindered derivative of the essential amino acid L-tyrosine. This modification is of significant interest in medicinal chemistry and peptide research for its ability to impart enhanced metabolic stability and conformational rigidity to bioactive peptides and peptidomimetics. It serves as a critical chiral building block for pharmaceutical R&D, particularly in the development of novel opioid receptor ligands, neuropeptide analogs, and other therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel opioid peptide analogs (e.g., Dmt-Tic pharmacophore derivatives) with potential analgesic properties.
• Peptide Research & Development: Incorporation into peptide sequences to study structure-activity relationships (SAR), enhance receptor selectivity, and improve resistance to enzymatic degradation.
• Medicinal Chemistry: Used as a constrained amino acid scaffold in drug discovery programs focused on GPCR targets, particularly within neuropharmacology.
• Biochemical Tool Compound: Serves as a standard or reference material in analytical laboratories for method development and quality control of related peptide APIs.
• Academic Research: Fundamental studies in organic synthesis, asymmetric chemistry, and the biochemistry of amino acid derivatives.

Basic Information

Product Name	2,6-Dimethyl-L-Tyrosine
CAS No.	123715-02-6
Molecular Formula	C11H15NO3
Molecular Weight	209.24 g/mol
Synonyms	DMT; (2S)-2-Amino-3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acid; L-2,6-Dimethyltyrosine; H-Dmt-OH; 2,6-Dimethyl-4-hydroxy-L-phenylalanine; D-2,6-Dimethyltyrosine (enantiomer); 2,6-DMT; Dmt(Tic) precursor
EINECS	Contact for details

Quality Control

We supply 2,6-Dimethyl-L-Tyrosine in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.