Description

Ethyl 4-(4-Hydroxy-3-Methoxyphenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, synthetically valuable dihydropyrimidinone (DHPM) derivative, a key scaffold in medicinal chemistry. This compound is essential for research and development in the pharmaceutical industry, serving as a critical intermediate for the synthesis of novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists working on cardiovascular, anti-inflammatory, and antiviral therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of dihydropyrimidinone-based drug candidates with potential calcium channel blocking activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial library synthesis to discover new therapeutic entities.
• Process Chemistry Development: Serves as a reference standard and starting material for scaling up and optimizing synthetic routes to active pharmaceutical ingredients (APIs).
• Academic Research: Employed in universities and research institutes for studying Biginelli reaction products and heterocyclic compound chemistry.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Ethyl 4-(4-Hydroxy-3-Methoxyphenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	123629-42-5
Molecular Formula	C15H18N2O5
Molecular Weight	306.32 g/mol
Synonyms	Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; DHPM derivative with vanillyl substituent; Biginelli product derivative; 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate; Contact for EINECS details.

Quality Control

Our Ethyl 4-(4-Hydroxy-3-Methoxyphenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.